You will normally need to take a combination of two different antibiotics, together with another drug that reduces your stomach acid. Lowering stomach acid helps the antibiotics work more effectively. This treatment is sometimes referred to astriple therapy.
Some of the drugs that are used in a triple therapy treatment include:
- proton-pump inhibitors (PPI), such as lansoprazole (Prevacid), esomeprazole (Nexium), pantoprazole (Protonix), or rabeprazole (AcipHex)
- metronidazole (for 7 to 14 days)
- amoxicillin (for 7 to 14 days)
Treatment may vary depending on your past medical history and if you have allergies to any of these medications.
After treatment, you will have a follow-up test for H. pylori. In most cases, only one round of antibiotics is needed to clear the infection, but you might need to take more, using different drugs.
Lifestyle and diet
There’s no evidence that food and nutrition play a role in preventing or causing peptic ulcer disease in people infected with H. pylori. However, spicy foods, alcohol, and smoking may worsen a peptic ulcer and prevent it from healing properly. Read about natural treatments for the H. pylori infection.